In the 1990s, the Darst lab had discovered RapA, a ATPase that clearly interacted ... His team set about using cryo-EM to examine how RNAP remains clamped to DNA after transcription termination ...

Cryo-EM structures reveal mechanism and inhibition of DNA targeting ... The dimeric MR complex composed of Mre11 nuclease and Rad50 ATPase detects and processes diverse and obstructed DNA ends by ...

Recent work on the molecular chaperonin GroEL and F1-ATPase has provided paradigms for this type of ... electron cryomicroscopy (cryo-EM) and fiber diffraction. Quantized elastic deformational model ...