The selective advantage for the establishment and, more interestingly, the maintenance of heterogeneity in tumors is unclear. Our results indicate that tumors benefit collectively from protecting ...

In addition, T H-17 cells seem to have a heterogeneous pattern of cytokine expression that includes the ability to produce IL-22 (ref. 4) or IL-10 (refs. 5 , 6 ).

Their data show how genetic and non-genetic factors determine the functional heterogeneity of blood cancer cells and reveal new therapeutic targets. In particular, under the selection pressure of ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Gastrointestinal (GI) cancers account for 26% of the global cancer incidence and 35% of all cancer-related deaths. Although the top 5 cancers in this group ...

Staining results in each reel were scored for areas with lowest (LS), highest (HS), and average (AS) expression, exclusively in the cancer cells. Heterogeneity score (HeS) was designed as the ...