The selective advantage for the establishment and, more interestingly, the maintenance of heterogeneity in tumors is unclear. Our results indicate that tumors benefit collectively from protecting ...

In addition, T H-17 cells seem to have a heterogeneous pattern of cytokine expression that includes the ability to produce IL-22 (ref. 4) or IL-10 (refs. 5 , 6 ).

Different from calculating the traditional mean methylation level of a predefined region (e.g., promoter CpG island), CHALM directly uses the aligned sequencing reads as input and quantifies the cell ...

Their data show how genetic and non-genetic factors determine the functional heterogeneity of blood cancer cells and reveal new therapeutic targets. In particular, under the selection pressure of ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq). Design We performed unbiased transcriptome-wide ...

Staining results in each reel were scored for areas with lowest (LS), highest (HS), and average (AS) expression, exclusively in the cancer cells. Heterogeneity score (HeS) was designed as the ...