Prokaryotic proteasomes are a rare breed ... which confers the broad substrate specificity that is reminiscent of eukaryotic systems. Finally, Li and co-workers determined the binding mode ...
The other half of this amazing system is the complex array of enzymes whose job it is to define proteasome specificity by choosing which cellular proteins to ubiquitinate and — just as crucially ...
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Scientists investigate a potential anti-aging drug that could preserve proteasomes and autophagy systemsMore information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner, Autophagy (2024). DOI: 10.1080 ...
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