Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the ...

Researchers at EPFL have opened up a world of possibilities in the computational design of molecular interactions for ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...

EPFL scientists have used deep learning to design new proteins that bind to complexes involving other small molecules like ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

The study, published today in the journal Cell Host & Microbe, sheds light on the molecular rules that govern ... helped discover the cholesterol-trafficking protein Niemann-Pick C1 (NPC1) as this ...