Protein structure at the heart of heart disease discovered
Low-density lipoproteins (LDL)—commonly known as bad cholesterol—have long been on scientists' radar as a major contributor ...
mskcc.org6y
The Stephen Long Lab: Research Overview
August, 2018 - Rozbeh and Chongyuan determine structures of the mitochondrial calcium uniporter MCU using cryo-EM (Baradaran, Wang, Siliciano & Long). It’s one cool channel and our first published ...
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Hormone receptor structure reveals how it functions in heart disease
Basically, the receptor acts as a communication channel ... in each cryo-EM image. "When you try to average all these images to determine the receptor's precise structure, you tend to end up ...
mskcc.org6y
RNA Decay
Our investigations of exosomes in budding yeast revealed that its central channel is essential ... helicase during unwinding and determined its structure by single particle cryoelectron microscopy ...