An international team of researchers has taken an important step toward understanding how gene expression is controlled ...

However, as the researchers discovered, this isn’t what happens in liver cells, also known as hepatocytes. In hepatocytes ...

In the experimental model of hepatic injury produced ... from the action of the toxin. Stellate hepatocytes have a crucial role in liver fibrogenesis. In response to fibrogenic influences (for ...

In fact, all six of the FDA-approved siRNA drugs target hepatocytes in the liver. "It's straightforward ... the silencing activity of another model siRNA compound delivered to the mice.

In fact, all six of the FDA-approved siRNA drugs target hepatocytes in the liver. "It's straightforward ... the silencing activity of another model siRNA compound delivered to the mice.

At the end of the experiment of each different model, mice were sacrificed following blood ... RIPK1 deficiency in hepatocytes sensitizes the liver to short-term fasting-induced liver injury and ...

The functional effect of PHLDA3 on liver injury was validated using lentiviral ... PHLDA3 overexpression correlated with the severity of hepatocyte injury in animal or cell model of ER stress. In ...

Mice with TonEBP haplodeficiency, and hepatocyte-specific and myeloid-specific TonEBP deletion ... predictor for recurrence and survival using the Cox regression hazard model. All data were analysed ...

Scientists at University of California San Diego School of Medicine have shed new light on the development of liver cancer, ...

Figure 3: a–c, Liver sections of rats after DMN administration. Sprague–Dawley rats 4–5 weeks old and 120–130 g in body weight were used. To produce liver cirrhosis, 1% DMN dissolved in ...