They coined the term "receptor-mediated endocytosis" to describe the entry of LDL into the cells (Goldstein & Brown 2009). In another series of experiments, Brown and Goldstein used electron ...

Inhibition of AMPA receptor endocytosis could help treat addiction to heroin. Van den Oever et al. have used a rat model to demonstrate that the link between re-exposure to preconditioned stimuli ...

Reduced receptor-mediated LDL endocytosis causing raised blood LDL cholesterol (LDL-C) is the main defect, but other abnormalities due to lack of LDL receptors include altered hepatic cholesterol ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

it sometimes requires an additional factor such as a protein that is a receptor for a specific chemical serving as a "named ticket to entry" into the cell. One can call its endocytosis that is a ...

This arrangement enables efficient receptor-mediated endocytosis. Local refinements of cryo-EM data identified the apoB100 β-belt as a continuous amphipathic structure wrapped around LDL’s ...

At the basic level, this work opened the field of receptor-mediated endocytosis, and at the clinical level it lay the conceptual groundwork for development of the statin drugs that lower blood ...

One key process in maintaining this equilibrium is endocytosis, the mechanism by which membrane components are internalised. Organisms have evolved various endocytic pathways, all relying on ...

The DRDC have the first set of animals (soman controls and bucillamine pretreated) completed and is now performing the assays looking at GABA receptor downregulation. Over the next few weeks data will ...

We have observed that anti-TNF antibodies bind to transmembrane TNF (tmTNF) and undergo endocytosis to the lysosome (1). We have developed a stable antibody drug conjugate (ADC), ABBV-3373, that has a ...