ALZFORUM | NETWORKING FOR A CURE
3 days ago · Could treating Alzheimer’s disease be as simple as inhaling xenon? Data from mice support this provocative idea. Huffing xenon for 40 minutes weekly shifted microglia from pro-inflammatory to phagocytic, allowing these immune cells to better corral plaques and prevent neurite degeneration.
Update on SORL1: Trafficking is Paramount, in Neurons and …
Jan 17, 2025 · Make a Comment. To make a comment you must login or register.. References Mutation Interactive Images Citations. SORL1 18 Jul 2023; News Citations. Sorting Out SORL1: 500+ Mutations Mapped, Prioritized in Alzforum Dataset 18 Jul 2023; When Missense Variants Derail SORL1 Traffic, Destination Is Dementia 18 Jul 2023; When SORL1 Dimerizes in Endosomes, Retromers Recycle APP Faster 1 Feb 2023
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1 day ago · “iAssembloids” Probe Glial Roles in Neuron Survival. Add To My AlzForum; 4 Comments; 24 Jan 2025. New 3D model shows how a tau kinase and Apoe4 astrocytes kill neurons through oxidative stress.
Plaques Spur Spread of Tangles by Sending Synapses into Overdrive
3 days ago · Scientists consider Alzheimer’s disease to be a secondary tauopathy induced by amyloid plaques. Given that Aβ and tau start aggregating in different regions of the brain, how does one set off the other? Combining functional MRI, Aβ-PET, and tau-PET, scientists led by Nicolai Franzmeier, Ludwig ...
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Jan 18, 2025 · Lactylation—a New Protein Modification That Slows Alzheimer’s? Add To My AlzForum; 3 Comments; 18 Jan 2025. In mice, lactylation of APP reduces amyloid deposits and slows disease progression.
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Dec 7, 2024 · In Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble. Add To My AlzForum; 07 Dec 2024. Research News Strapped with an extra APP, people with Down’s syndrome are all but destined to. Do CSF and Plasma …
Revised Again: Alzheimer's Diagnostic Criteria Get Another …
Sep 16, 2022 · 17 Aug 2023. Diagnostic criteria for Alzheimer’s disease were revised only five years ago, but the field has learned a lot since then. At the Alzheimer’s Association International Conference, held last month in Amsterdam, Clifford Jack of the Mayo Clinic in Rochester, Minnesota, proposed updates to the current “ATN” system. Like the 2018 criteria, the new ones are the product of a ...
2023—A Bumper Year for the Treatment and Science of Alzheimer's
Dec 26, 2023 · Biomarkers for other neurodegenerative diseases are on the horizon. After decades of effort, α-synuclein PET tracers look promising. 18F-ACI-12589, previously shown to detect synuclein deposits only in people with multiple system atrophy, lit up in people with PD or DLB who have a duplication of the synuclein gene, implying that the tracer works best when synuclein burden is high.
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Dec 11, 2024 · Is Your Brain Aging Fast? Plasma Proteins Might Tell. Add To My AlzForum; 7 Comments; 11 Dec 2024. Eight proteins in blood associate with faster brain aging, five with slower.
2022, a Year in Review - ALZFORUM
Sep 16, 2022 · 15 Jan 2023. Part 1 of 2 The year 2022 was a turning point in Alzheimer's research. It began with the Aduhelm debacle fresh on people's mind. It ended with reassurance that amyloid removal indeed helps people with the disease, when lecanemab's Phase 3 data showed a slowing of cognitive decline.